Research ArticleBIOPHYSICS

Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T

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Science Advances  05 Aug 2020:
Vol. 6, no. 32, eabc1449
DOI: 10.1126/sciadv.abc1449

Article Information

vol. 6 no. 32

Online ISSN: 
History: 
  • Received for publication April 8, 2020
  • Accepted for publication June 22, 2020
  • .

Author Information

  1. Lanlan Yu1,2,
  2. Wenbo Zhang1,
  3. Wendi Luo3,4,
  4. Robert L. Dupont5,
  5. Yang Xu5,
  6. Yibing Wang6,
  7. Bin Tu3,
  8. Haiyan Xu2,
  9. Xiaoguang Wang5,
  10. Qiaojun Fang3,*,
  11. Yanlian Yang3,
  12. Chen Wang3 and
  13. Chenxuan Wang1,*
  1. 1State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P. R. China.
  2. 2Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, P. R. China.
  3. 3CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.
  4. 4Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing 100190, P. R. China.
  5. 5William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.
  6. 6State Key Laboratory of Bioreactor Engineering, Biomedical Nanotechnology Center, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, P. R. China.
  1. *Corresponding author. Email: wangcx{at}ibms.pumc.edu.cn (Chenxuan Wang); fangqj{at}nanoctr.cn (Q.F.)

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