Research ArticleIMMUNOLOGY
Altered 3D chromatin structure permits inversional recombination at the IgH locus
- View ORCID ProfileXiang Qiu1,*,
- View ORCID ProfileFei Ma1,*,
- Mingming Zhao1,
- View ORCID ProfileYaqiang Cao2,
- View ORCID ProfileLillian Shipp1,
- View ORCID ProfileAngela Liu1,
- View ORCID ProfileArun Dutta1,
- View ORCID ProfileAmit Singh1,
- Fatima Zohra Braikia1,
- View ORCID ProfileSupriyo De3,
- William H. Wood III3,
- View ORCID ProfileKevin G. Becker3,
- View ORCID ProfileWeiqiang Zhou4,
- View ORCID ProfileHongkai Ji4,
- Keji Zhao2,
- Michael L. Atchison5 and
- View ORCID ProfileRanjan Sen1,†
- 1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
- 2Laboratory of Epigenome Biology, Systems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
- 3Laboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.
- 4Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
- 5Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
- ↵†Corresponding author. Email: senranja{at}grc.nia.nih.gov
↵* These authors contributed equally to this work as co-first authors.
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Science Advances 14 Aug 2020:
Vol. 6, no. 33, eaaz8850
DOI: 10.1126/sciadv.aaz8850
Vol. 6, no. 33, eaaz8850
DOI: 10.1126/sciadv.aaz8850
Xiang Qiu
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Fei Ma
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Mingming Zhao
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Yaqiang Cao
2Laboratory of Epigenome Biology, Systems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
Lillian Shipp
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Angela Liu
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Arun Dutta
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Amit Singh
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Fatima Zohra Braikia
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Supriyo De
3Laboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.
William H. Wood III
3Laboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.
Kevin G. Becker
3Laboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.
Weiqiang Zhou
4Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Hongkai Ji
4Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Keji Zhao
2Laboratory of Epigenome Biology, Systems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
Michael L. Atchison
5Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ranjan Sen
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
