Research ArticleMOLECULAR BIOLOGY

Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

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Science Advances  12 Aug 2020:
Vol. 6, no. 33, eaba6617
DOI: 10.1126/sciadv.aba6617

Article Information

vol. 6 no. 33

Online ISSN: 
History: 
  • Received for publication December 20, 2019
  • Accepted for publication July 1, 2020
  • .

Author Information

  1. Mateusz Stoszko1,
  2. Abdullah M. S. Al-Hatmi2,3,4,*,
  3. Anton Skriba5,*,
  4. Michael Roling1,*,
  5. Enrico Ne1,*,
  6. Raquel Crespo1,*,
  7. Yvonne M. Mueller6,*,
  8. Mohammad Javad Najafzadeh2,7,*,
  9. Joyce Kang8,
  10. Renata Ptackova5,
  11. Elizabeth LeMasters1,
  12. Pritha Biswas1,
  13. Alessia Bertoldi1,9,
  14. Tsung Wai Kan1,
  15. Elisa de Crignis1,
  16. Miroslav Sulc5,
  17. Joyce H.G. Lebbink10,
  18. Casper Rokx11,
  19. Annelies Verbon11,
  20. Wilfred van Ijcken12,
  21. Peter D. Katsikis6,
  22. Robert-Jan Palstra1,
  23. Vladimir Havlicek5,
  24. Sybren de Hoog2,3 and
  25. Tokameh Mahmoudi1,
  1. 1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
  2. 2Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands.
  3. 3Center of Expertise in Mycology of Radboud UMC/CWZ, Nijmegen, Netherlands.
  4. 4Ministry of Health, Directorate General of Health Services, Ibri, Oman.
  5. 5Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, CZ 14220 Prague 4, Czech Republic.
  6. 6Department of Immunology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
  7. 7Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  8. 8Key Laboratory of Environmental Pollution Monitoring/Disease Control, Ministry of Education and Guizhou Talent Base of Microbes and Human Health, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, P. R. China.
  9. 9Microbiology Section, Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Bologna, Italy.
  10. 10Departments of Molecular Genetics and Radiation Oncology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands.
  11. 11Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands.
  12. 12Erasmus MC Genomics Core Facility, Department of Cell Biology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands.
  1. Corresponding author. Email: t.mahmoudi{at}erasmusmc.nl
  • * These authors contributed equally to this work.

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