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Research ArticleMOLECULAR BIOLOGY
Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency
- View ORCID ProfileMateusz Stoszko1,
- View ORCID ProfileAbdullah M. S. Al-Hatmi2,3,4,*,
- Anton Skriba5,*,
- Michael Roling1,*,
- Enrico Ne1,*,
- Raquel Crespo1,*,
- View ORCID ProfileYvonne M. Mueller6,*,
- Mohammad Javad Najafzadeh2,7,*,
- Joyce Kang8,
- View ORCID ProfileRenata Ptackova5,
- Elizabeth LeMasters1,
- Pritha Biswas1,
- View ORCID ProfileAlessia Bertoldi1,9,
- Tsung Wai Kan1,
- Elisa de Crignis1,
- Miroslav Sulc5,
- Joyce H.G. Lebbink10,
- Casper Rokx11,
- Annelies Verbon11,
- View ORCID ProfileWilfred van Ijcken12,
- View ORCID ProfilePeter D. Katsikis6,
- View ORCID ProfileRobert-Jan Palstra1,
- View ORCID ProfileVladimir Havlicek5,
- Sybren de Hoog2,3 and
- View ORCID ProfileTokameh Mahmoudi1,†
- 1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
- 2Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands.
- 3Center of Expertise in Mycology of Radboud UMC/CWZ, Nijmegen, Netherlands.
- 4Ministry of Health, Directorate General of Health Services, Ibri, Oman.
- 5Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, CZ 14220 Prague 4, Czech Republic.
- 6Department of Immunology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
- 7Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
- 8Key Laboratory of Environmental Pollution Monitoring/Disease Control, Ministry of Education and Guizhou Talent Base of Microbes and Human Health, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, P. R. China.
- 9Microbiology Section, Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Bologna, Italy.
- 10Departments of Molecular Genetics and Radiation Oncology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands.
- 11Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands.
- 12Erasmus MC Genomics Core Facility, Department of Cell Biology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands.
- ↵†Corresponding author. Email: t.mahmoudi{at}erasmusmc.nl
↵* These authors contributed equally to this work.
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Science Advances 12 Aug 2020:
Vol. 6, no. 33, eaba6617
DOI: 10.1126/sciadv.aba6617
Vol. 6, no. 33, eaba6617
DOI: 10.1126/sciadv.aba6617
Mateusz Stoszko
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Abdullah M. S. Al-Hatmi
2Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands.
3Center of Expertise in Mycology of Radboud UMC/CWZ, Nijmegen, Netherlands.
4Ministry of Health, Directorate General of Health Services, Ibri, Oman.
Anton Skriba
5Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, CZ 14220 Prague 4, Czech Republic.
Michael Roling
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Enrico Ne
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Raquel Crespo
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Yvonne M. Mueller
6Department of Immunology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Mohammad Javad Najafzadeh
2Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands.
7Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Joyce Kang
8Key Laboratory of Environmental Pollution Monitoring/Disease Control, Ministry of Education and Guizhou Talent Base of Microbes and Human Health, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, P. R. China.
Renata Ptackova
5Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, CZ 14220 Prague 4, Czech Republic.
Elizabeth LeMasters
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Pritha Biswas
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Alessia Bertoldi
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
9Microbiology Section, Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Bologna, Italy.
Tsung Wai Kan
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Elisa de Crignis
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Miroslav Sulc
5Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, CZ 14220 Prague 4, Czech Republic.
Joyce H.G. Lebbink
10Departments of Molecular Genetics and Radiation Oncology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Casper Rokx
11Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands.
Annelies Verbon
11Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands.
Wilfred van Ijcken
12Erasmus MC Genomics Core Facility, Department of Cell Biology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands.
Peter D. Katsikis
6Department of Immunology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Robert-Jan Palstra
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Vladimir Havlicek
5Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, CZ 14220 Prague 4, Czech Republic.
Sybren de Hoog
2Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands.
3Center of Expertise in Mycology of Radboud UMC/CWZ, Nijmegen, Netherlands.
Tokameh Mahmoudi
1Department of Biochemistry, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands.
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