Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms—An intravital imaging study in mice

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Science Advances  14 Aug 2020:
Vol. 6, no. 33, eabb1112
DOI: 10.1126/sciadv.abb1112

Article Information

vol. 6 no. 33

Online ISSN: 
  • Received for publication January 30, 2020
  • Accepted for publication July 1, 2020
  • .

Author Information

  1. Shuang Tian1,2,
  2. Linzhu Su1,2,
  3. Yong Liu1,2,*,
  4. Jingjing Cao1,
  5. Guang Yang1,2,
  6. Yijin Ren3,
  7. Fan Huang4,
  8. Jianfeng Liu4,,
  9. Yingli An1,
  10. Henny C. van der Mei2,,
  11. Henk J. Busscher2, and
  12. Linqi Shi1,
  1. 1State Key Laboratory of Medicinal Chemical Biology; Key Laboratory of Functional Polymer Materials, Ministry of Education; and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P.R. China.
  2. 2University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.
  3. 3University of Groningen and University Medical Center Groningen, Department of Orthodontics, Hanzeplein 1, 9700 RB Groningen, Netherlands.
  4. 4Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, P.R. China.
  1. Corresponding author. Email: liujianfeng{at} (J.L.); h.c.van.der.mei{at} (H.C.v.d.M.); h.j.busscher{at} (H.J.B.); shilinqi{at} (L.Sh.)
  • * Present address: Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory of Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.


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