Research ArticleENGINEERING
3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration
- View ORCID ProfileFiona E. Freeman1,2,
- Pierluca Pitacco1,2,
- View ORCID ProfileLieke H. A. van Dommelen3,
- View ORCID ProfileJessica Nulty1,2,
- View ORCID ProfileDavid C. Browe1,2,
- Jung-Youn Shin4,
- View ORCID ProfileEben Alsberg4,5 and
- View ORCID ProfileDaniel J. Kelly1,2,6,7,*
- 1Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
- 2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland.
- 3Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
- 4Departments of Biomedical Engineering and Orthopaedic Surgery, Case Western Reserve University, Cleveland, OH 44106, USA.
- 5Departments of Biomedical Engineering, Pharmacology, Orthopaedics, and Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
- 6Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.
- 7Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland.
- ↵*Corresponding author. Email: kellyd9{at}tcd.ie
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Science Advances 14 Aug 2020:
Vol. 6, no. 33, eabb5093
DOI: 10.1126/sciadv.abb5093
Vol. 6, no. 33, eabb5093
DOI: 10.1126/sciadv.abb5093
Fiona E. Freeman
1Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland.
Pierluca Pitacco
1Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland.
Lieke H. A. van Dommelen
3Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Jessica Nulty
1Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland.
David C. Browe
1Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland.
Jung-Youn Shin
4Departments of Biomedical Engineering and Orthopaedic Surgery, Case Western Reserve University, Cleveland, OH 44106, USA.
Eben Alsberg
4Departments of Biomedical Engineering and Orthopaedic Surgery, Case Western Reserve University, Cleveland, OH 44106, USA.
5Departments of Biomedical Engineering, Pharmacology, Orthopaedics, and Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Daniel J. Kelly
1Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland.
6Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.
7Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland.
