Research ArticleIMMUNOLOGY

Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice

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Science Advances  14 Aug 2020:
Vol. 6, no. 33, eabb7238
DOI: 10.1126/sciadv.abb7238

Article Information

vol. 6 no. 33

Online ISSN: 
History: 
  • Received for publication March 13, 2020
  • Accepted for publication July 2, 2020
  • .

Author Information

  1. Hanh Chi Do-Umehara1,*,
  2. Cong Chen2,*,
  3. Qiao Zhang2,*,
  4. Alexander V. Misharin2,
  5. Hiam Abdala-Valencia2,
  6. S. Marina Casalino-Matsuda2,
  7. Paul A. Reyfman2,
  8. Kishore R. Anekalla2,
  9. Francisco J. Gonzalez-Gonzalez2,
  10. Marc A. Sala2,
  11. Chao Peng3,
  12. Ping Wu3,
  13. Catherine C. L. Wong4,
  14. Ravi Kalhan2,
  15. Ankit Bharat2,5,
  16. Harris Perlman6,
  17. Karen M. Ridge2,
  18. Jacob I. Sznajder2,
  19. Peter H. S. Sporn2,11,
  20. Navdeep S. Chandel2,
  21. Jindan Yu7,
  22. Xiangdong Fu8,
  23. Irina Petrache9,10,
  24. Rubin Tuder10,
  25. G. R. Scott Budinger2,11, and
  26. Jing Liu1,
  1. 1Department of Surgery, College of Medicine and University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.
  2. 2Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  3. 3National Facility for Protein Science in Shanghai, Zhangjiang Lab, SARI, CAS, Shanghai 201210, China.
  4. 4Peking University School of Pharmaceutical Science, Beijing 100191, China.
  5. 5Division of Thoracic Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  6. 6Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  7. 7Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  8. 8Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA; Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA.
  9. 9National Jewish Health, 1400 Jackson Street, Molly Blank Building, J203, Denver, CO 80206, USA.
  10. 10University of Colorado at Denver Health Sciences Center, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Denver, CO 80206, USA.
  11. 11Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA.
  1. Corresponding author. Email: jinglius{at}uic.edu (J.L.); s-buding{at}northwestern.edu (G.R.S.B.)
  • * These authors contributed equally to this work.

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