Anti-α4β7 monoclonal antibody–conjugated nanoparticles block integrin α4β7 on intravaginal T cells in rhesus macaques

Sidi Yang; Geraldine Arrode-Bruses; Ines Frank; Brooke Grasperge; James Blanchard; Agegnehu Gettie; Elena Martinelli; Emmanuel A. Ho

doi:10.1126/sciadv.abb9853

Research ArticleHEALTH AND MEDICINE

Anti-α₄β₇ monoclonal antibody–conjugated nanoparticles block integrin α₄β₇ on intravaginal T cells in rhesus macaques

View ORCID ProfileSidi Yang¹,
View ORCID ProfileGeraldine Arrode-Bruses²,
View ORCID ProfileInes Frank²,
View ORCID ProfileBrooke Grasperge³,
View ORCID ProfileJames Blanchard ³,
Agegnehu Gettie⁴,
View ORCID ProfileElena Martinelli ²,*,† and
View ORCID ProfileEmmanuel A. Ho ¹,*,†

¹School of Pharmacy, University of Waterloo, 10 Victoria St. S A, Kitchener, Ontario N2G 1C5, Canada.
²Center for Biomedical Research, Population Council, One Dag Hammarskjold Plaza, New York, NY 10017, USA.
³Tulane National Primate Research Center, Tulane University, 6823 St. Charles Ave., New Orleans, LA 70118, USA.
⁴Aaron Diamond AIDS Research Center, Rockefeller University, 455 1st Avenue #7, New York, NY 10016, USA.

↵*Corresponding author. Email: emmanuel.ho{at}uwaterloo.ca (E.A.H.); emartinelli{at}popcouncil.org (E.M.)

↵† These authors contributed equally to this work.

See allHide authors and affiliations

Science Advances 21 Aug 2020:
Vol. 6, no. 34, eabb9853
DOI: 10.1126/sciadv.abb9853

Sidi Yang

1School of Pharmacy, University of Waterloo, 10 Victoria St. S A, Kitchener, Ontario N2G 1C5, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sidi Yang

Geraldine Arrode-Bruses

2Center for Biomedical Research, Population Council, One Dag Hammarskjold Plaza, New York, NY 10017, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Geraldine Arrode-Bruses

Ines Frank

2Center for Biomedical Research, Population Council, One Dag Hammarskjold Plaza, New York, NY 10017, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ines Frank

Brooke Grasperge

3Tulane National Primate Research Center, Tulane University, 6823 St. Charles Ave., New Orleans, LA 70118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Brooke Grasperge

James Blanchard

3Tulane National Primate Research Center, Tulane University, 6823 St. Charles Ave., New Orleans, LA 70118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for James Blanchard

Agegnehu Gettie

4Aaron Diamond AIDS Research Center, Rockefeller University, 455 1st Avenue #7, New York, NY 10016, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Elena Martinelli

2Center for Biomedical Research, Population Council, One Dag Hammarskjold Plaza, New York, NY 10017, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Elena Martinelli
For correspondence: emmanuel.ho@uwaterloo.ca emartinelli@popcouncil.org

Emmanuel A. Ho

1School of Pharmacy, University of Waterloo, 10 Victoria St. S A, Kitchener, Ontario N2G 1C5, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Emmanuel A. Ho
For correspondence: emmanuel.ho@uwaterloo.ca emartinelli@popcouncil.org

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all . Please read our guidelines before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Anti-α₄β₇ monoclonal antibody–conjugated nanoparticles block integrin α₄β₇ on intravaginal T cells in rhesus macaques

Plain text

Vertical Tabs

Science Advances

Article Tools

Anti-α₄β₇ monoclonal antibody–conjugated nanoparticles block integrin α₄β₇ on intravaginal T cells in rhesus macaques

Citation Manager Formats

Anti-α₄β₇ monoclonal antibody–conjugated nanoparticles block integrin α₄β₇ on intravaginal T cells in rhesus macaques

My saved folders

Stay Connected to Science Advances

Citing Articles in:

share

Plain text

Vertical Tabs

Science Advances

Article Tools