Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest

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Science Advances  28 Aug 2020:
Vol. 6, no. 35, eaaz4796
DOI: 10.1126/sciadv.aaz4796

Article Information

vol. 6 no. 35

Online ISSN: 
  • Received for publication September 24, 2019
  • Accepted for publication July 15, 2020
  • .

Author Information

  1. Aijie Xin1,2,*,
  2. Ronggui Qu1,*,
  3. Guowu Chen1,*,
  4. Ling Zhang1,3,4,*,
  5. Junling Chen1,
  6. Chengqiu Tao3,
  7. Jing Fu1,
  8. Jianan Tang2,
  9. Yanfei Ru2,
  10. Ying Chen1,
  11. Xiandong Peng1,
  12. Huijuan Shi2,,
  13. Feng Zhang1,2,3,4,5, and
  14. Xiaoxi Sun1,4,6,
  1. 1Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
  2. 2NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Pharmacy, Fudan University, Shanghai, China.
  3. 3State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
  4. 4Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
  5. 5State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
  6. 6Department of Endocrinology and Reproductive Medicine, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
  1. Corresponding author. Email: xiaoxi_sun{at} (X.S.); zhangfeng{at} (F.Z.); shihuijuan2011{at} (H.S.)
  • * These authors contributed equally to this work.


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