Research ArticleHEALTH AND MEDICINE
Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia
- View ORCID ProfileC. A. Gilroy1,2,
- View ORCID ProfileM. E. Capozzi3,
- A. K. Varanko1,
- View ORCID ProfileJ. Tong3,4,
- D. A. D'Alessio3,4,
- View ORCID ProfileJ. E. Campbell3,5 and
- View ORCID ProfileA. Chilkoti1,*
- 1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
- 2Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA.
- 3Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
- 4Department of Medicine, Duke University, Durham, NC 27701, USA.
- 5Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27701, USA.
- ↵*Corresponding author. Email: chilkoti{at}duke.edu
See allHide authors and affiliations
Science Advances 26 Aug 2020:
Vol. 6, no. 35, eaaz9890
DOI: 10.1126/sciadv.aaz9890
Vol. 6, no. 35, eaaz9890
DOI: 10.1126/sciadv.aaz9890
C. A. Gilroy
1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
2Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA.
M. E. Capozzi
3Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
A. K. Varanko
1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
J. Tong
3Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
4Department of Medicine, Duke University, Durham, NC 27701, USA.
D. A. D'Alessio
3Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
4Department of Medicine, Duke University, Durham, NC 27701, USA.
J. E. Campbell
3Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
5Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27701, USA.
A. Chilkoti
1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
