Research ArticlePHYSIOLOGY

Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues

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Science Advances  28 Aug 2020:
Vol. 6, no. 35, eaba2795
DOI: 10.1126/sciadv.aba2795

Article Information

vol. 6 no. 35

Online ISSN: 
  • Received for publication January 22, 2020
  • Accepted for publication July 14, 2020
  • .

Author Information

  1. Jared L. Zitnay1,2,
  2. Gang Seob Jung3,*,
  3. Allen H. Lin1,2,
  4. Zhao Qin3,,
  5. Yang Li1,
  6. S. Michael Yu1,4,
  7. Markus J. Buehler3 and
  8. Jeffrey A. Weiss1,2,5,
  1. 1Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
  2. 2Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT 84112, USA.
  3. 3Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  4. 4Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84132, USA.
  5. 5Department of Orthopaedics and School of Computing, University of Utah, Salt Lake City, UT 84112, USA.
  1. Corresponding author. Email: jeff.weiss{at}
  • * Present address: Computational Sciences and Engineering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.

  • Present address: Civil and Environmental Engineering, Syracuse University, Syracuse, NY 13244, USA.


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Oct 202039266112
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