Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Zhongxiao Wang; Chi-Hsiu Liu; Shuo Huang; Zhongjie Fu; Yohei Tomita; William R. Britton; Steve S. Cho; Chuck T. Chen; Ye Sun; Jian-xing Ma; Xi He; Jing Chen

doi:10.1126/sciadv.aba7457

Research ArticleMOLECULAR BIOLOGY

Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

View ORCID ProfileZhongxiao Wang¹,
View ORCID ProfileChi-Hsiu Liu¹,
View ORCID ProfileShuo Huang¹,
Zhongjie Fu¹,
View ORCID ProfileYohei Tomita¹,
View ORCID ProfileWilliam R. Britton¹,
Steve S. Cho¹,
Chuck T. Chen²,
Ye Sun ¹,
Jian-xing Ma³,
Xi He⁴ and
View ORCID ProfileJing Chen ¹,*

¹Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
²Section on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, USA.
³Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
⁴The F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.

↵*Corresponding author. Email: jing.chen{at}childrens.harvard.edu

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Science Advances 28 Aug 2020:
Vol. 6, no. 35, eaba7457
DOI: 10.1126/sciadv.aba7457

Zhongxiao Wang

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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ORCID record for Zhongxiao Wang

Chi-Hsiu Liu

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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ORCID record for Chi-Hsiu Liu

Shuo Huang

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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ORCID record for Shuo Huang

Zhongjie Fu

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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Yohei Tomita

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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ORCID record for Yohei Tomita

William R. Britton

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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ORCID record for William R. Britton

Steve S. Cho

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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Chuck T. Chen

2Section on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, USA.

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Ye Sun

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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Jian-xing Ma

3Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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Xi He

4The F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.

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Jing Chen

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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ORCID record for Jing Chen
For correspondence: jing.chen@childrens.harvard.edu

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Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

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