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Research ArticleMOLECULAR BIOLOGY
Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier
- View ORCID ProfileZhongxiao Wang1,
- View ORCID ProfileChi-Hsiu Liu1,
- View ORCID ProfileShuo Huang1,
- Zhongjie Fu1,
- View ORCID ProfileYohei Tomita1,
- View ORCID ProfileWilliam R. Britton1,
- Steve S. Cho1,
- Chuck T. Chen2,
- Ye Sun1,
- Jian-xing Ma3,
- Xi He4 and
- View ORCID ProfileJing Chen1,*
- 1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
- 2Section on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, USA.
- 3Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
- 4The F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
- ↵*Corresponding author. Email: jing.chen{at}childrens.harvard.edu
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Science Advances 28 Aug 2020:
Vol. 6, no. 35, eaba7457
DOI: 10.1126/sciadv.aba7457
Vol. 6, no. 35, eaba7457
DOI: 10.1126/sciadv.aba7457
Zhongxiao Wang
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Chi-Hsiu Liu
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Shuo Huang
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Zhongjie Fu
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Yohei Tomita
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
William R. Britton
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Steve S. Cho
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Chuck T. Chen
2Section on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, USA.
Ye Sun
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Jian-xing Ma
3Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Xi He
4The F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
Jing Chen
1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
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