Research ArticleIMMUNOLOGY
Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity
- View ORCID ProfileElias H. Augestad1,
- Matteo Castelli2,
- View ORCID ProfileNicola Clementi2,
- View ORCID ProfileLuisa J. Ströh3,
- View ORCID ProfileThomas Krey3,4,5,6,7,
- Roberto Burioni2,
- View ORCID ProfileNicasio Mancini2,
- View ORCID ProfileJens Bukh1 and
- View ORCID ProfileJannick Prentoe1,*
- 1Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
- 2Laboratory of Microbiology and Virology, Università “Vita-Salute” San Raffaele, Milano, 20132, Italy.
- 3Institute of Virology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
- 4German Center for Infection Research (DZIF), partner sites Hannover-Braunschweig and Hamburg-Lübeck-Borstel-Riems, Germany.
- 5Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of Luebeck, Ratzeburger Allee 160, 23562 Luebeck, Germany.
- 6Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
- 7Centre for Structural Systems Biology (CSSB), Notkestraße 85, 22607 Hamburg, Germany.
- ↵*Corresponding author. Email: jprentoe{at}sund.ku.dk
See allHide authors and affiliations
Science Advances 26 Aug 2020:
Vol. 6, no. 35, eabb5938
DOI: 10.1126/sciadv.abb5938
Vol. 6, no. 35, eabb5938
DOI: 10.1126/sciadv.abb5938
Elias H. Augestad
1Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Matteo Castelli
2Laboratory of Microbiology and Virology, Università “Vita-Salute” San Raffaele, Milano, 20132, Italy.
Nicola Clementi
2Laboratory of Microbiology and Virology, Università “Vita-Salute” San Raffaele, Milano, 20132, Italy.
Luisa J. Ströh
3Institute of Virology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Thomas Krey
3Institute of Virology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
4German Center for Infection Research (DZIF), partner sites Hannover-Braunschweig and Hamburg-Lübeck-Borstel-Riems, Germany.
5Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of Luebeck, Ratzeburger Allee 160, 23562 Luebeck, Germany.
6Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
7Centre for Structural Systems Biology (CSSB), Notkestraße 85, 22607 Hamburg, Germany.
Roberto Burioni
2Laboratory of Microbiology and Virology, Università “Vita-Salute” San Raffaele, Milano, 20132, Italy.
Nicasio Mancini
2Laboratory of Microbiology and Virology, Università “Vita-Salute” San Raffaele, Milano, 20132, Italy.
Jens Bukh
1Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Jannick Prentoe
1Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
