Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity

Jingjing Liang; Huifang Wang; Wenxiu Ding; Jianxiang Huang; Xuefei Zhou; Huiyang Wang; Xue Dong; Guangyao Li; Enguo Chen; Fei Zhou; Hongjie Fan; Jingya Xia; Bo Shen; Da Cai; Pengxun Lan; Hanliang Jiang; Jun Ling; Zhen Cheng; Xiangrui Liu; Jihong Sun

doi:10.1126/sciadv.abc3646

Research ArticleCANCER

Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity

View ORCID ProfileJingjing Liang ¹,*,
View ORCID ProfileHuifang Wang²,*,
View ORCID ProfileWenxiu Ding³,
View ORCID ProfileJianxiang Huang²,
View ORCID ProfileXuefei Zhou²,
View ORCID ProfileHuiyang Wang³,
View ORCID ProfileXue Dong¹,
View ORCID ProfileGuangyao Li¹,
View ORCID ProfileEnguo Chen⁴,
View ORCID ProfileFei Zhou¹,
View ORCID ProfileHongjie Fan¹,
View ORCID ProfileJingya Xia¹,
View ORCID ProfileBo Shen¹,
View ORCID ProfileDa Cai¹,
View ORCID ProfilePengxun Lan¹,
View ORCID ProfileHanliang Jiang⁵,
View ORCID ProfileJun Ling⁶,
View ORCID ProfileZhen Cheng⁷,†,
View ORCID ProfileXiangrui Liu ¹,²,† and
View ORCID ProfileJihong Sun ¹,†

¹Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
²Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
³Second Clinical Medical College, Zhejiang Chinese Medical University, Quzhou 310053, China.
⁴Department of Respiratory and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
⁵Pulmonary and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
⁶MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
⁷Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Stanford University Medical Center, Stanford, CA 94305, USA.

↵†Corresponding author. Email: sunjihong{at}zju.edu.cn (J.S.); xiangrui{at}zju.edu.cn (X.L.); zcheng{at}stanford.edu (Z.C.)

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Advances 28 Aug 2020:
Vol. 6, no. 35, eabc3646
DOI: 10.1126/sciadv.abc3646

Jingjing Liang

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jingjing Liang

Huifang Wang

2Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Huifang Wang

Wenxiu Ding

3Second Clinical Medical College, Zhejiang Chinese Medical University, Quzhou 310053, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Wenxiu Ding

Jianxiang Huang

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jianxiang Huang

Xuefei Zhou

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Xuefei Zhou

Huiyang Wang

3Second Clinical Medical College, Zhejiang Chinese Medical University, Quzhou 310053, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Huiyang Wang

Xue Dong

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Xue Dong

Guangyao Li

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Guangyao Li

Enguo Chen

4Department of Respiratory and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Enguo Chen

Fei Zhou

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Fei Zhou

Hongjie Fan

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hongjie Fan

Jingya Xia

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jingya Xia

Bo Shen

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Bo Shen

Da Cai

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Da Cai

Pengxun Lan

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Pengxun Lan

Hanliang Jiang

5Pulmonary and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hanliang Jiang

Jun Ling

6MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jun Ling

Zhen Cheng

7Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Stanford University Medical Center, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Zhen Cheng
For correspondence: sunjihong@zju.edu.cn xiangrui@zju.edu.cn zcheng@stanford.edu

Xiangrui Liu

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Xiangrui Liu
For correspondence: sunjihong@zju.edu.cn xiangrui@zju.edu.cn zcheng@stanford.edu

Jihong Sun

1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jihong Sun
For correspondence: sunjihong@zju.edu.cn xiangrui@zju.edu.cn zcheng@stanford.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all . Please read our guidelines before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity

Plain text

Vertical Tabs

Science Advances

Article Tools