Research ArticleIMMUNOLOGY

B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis

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Science Advances  09 Sep 2020:
Vol. 6, no. 37, eabb6296
DOI: 10.1126/sciadv.abb6296

Article Information

vol. 6 no. 37

Online ISSN: 
  • Received for publication March 9, 2020
  • Accepted for publication July 28, 2020
  • .

Author Information

  1. Qiu-Hui Zeng1,*,
  2. Yuan Wei1,*,
  3. Xiang-Ming Lao2,*,
  4. Dong-Ping Chen1,*,
  5. Chun-Xiang Huang1,
  6. Qian-Yi Lin2,
  7. Min He3,
  8. Yuan Liao4,
  9. Limin Zheng1,
  10. Bo Li5,
  11. Guang-Bo Zhang6,,
  12. Yun Chen7,8, and
  13. Dong-Ming Kuang1,2,9,
  1. 1MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, P.R. China.
  2. 2State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, P.R. China.
  3. 3Department of Clinical Laboratory, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, P.R. China.
  4. 4Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, P.R. China.
  5. 5Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, P.R. China.
  6. 6Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
  7. 7Department of Immunology, Key Laboratory of Immune Microenvironment and Disease, Nanjing Medical University, Nanjing 211166, China.
  8. 8Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China.
  9. 9Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, P.R. China.
  1. Corresponding author. Email: kdming{at} (D.-M.K.); chenyun{at} (Y.C.); zhanggbsuzhou{at} (G.-B.Z.)
  • * These authors contributed equally to this work.


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