Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers

Noam Shental; Shlomia Levy; Vered Wuvshet; Shosh Skorniakov; Bar Shalem; Aner Ottolenghi; Yariv Greenshpan; Rachel Steinberg; Avishay Edri; Roni Gillis; Michal Goldhirsh; Khen Moscovici; Sinai Sachren; Lilach M. Friedman; Lior Nesher; Yonat Shemer-Avni; Angel Porgador; Tomer Hertz

doi:10.1126/sciadv.abc5961

Research ArticleCORONAVIRUS

Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers

View ORCID ProfileNoam Shental¹,*,†,
Shlomia Levy²,³,‡,
Vered Wuvshet²,³,‡,
Shosh Skorniakov²,³,‡,
Bar Shalem⁴,
View ORCID ProfileAner Ottolenghi²,³,
Yariv Greenshpan²,³,
Rachel Steinberg⁵,
View ORCID ProfileAvishay Edri²,³,
View ORCID ProfileRoni Gillis⁶,
Michal Goldhirsh⁶,
View ORCID ProfileKhen Moscovici⁶,
View ORCID ProfileSinai Sachren³,
View ORCID ProfileLilach M. Friedman²,³,
View ORCID ProfileLior Nesher⁵,
Yonat Shemer-Avni²,⁵,
View ORCID ProfileAngel Porgador²,³,*,† and
View ORCID ProfileTomer Hertz²,³,⁷,*

¹Department of Computer Science, The Open University of Israel, Ra’anana, Israel.
²Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
³National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁴Department of Computer Science, Bar-Ilan University, Ramat Gan, Israel.
⁵Soroka University Medical Center, Beer-Sheva, Israel.
⁶Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁷Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

↵†Corresponding author. Email: angel{at}bgu.ac.il (A.P.); shental{at}openu.ac.il (N.S.); thertz{at}bgu.ac.il (T.H.)

↵* These authors contributed equally to this work as co-senior authors.
↵‡ These authors contributed equally to this work.

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Science Advances 11 Sep 2020:
Vol. 6, no. 37, eabc5961
DOI: 10.1126/sciadv.abc5961

Noam Shental

1Department of Computer Science, The Open University of Israel, Ra’anana, Israel.

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ORCID record for Noam Shental
For correspondence: angel@bgu.ac.il shental@openu.ac.il thertz@bgu.ac.il

Shlomia Levy

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Vered Wuvshet

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Shosh Skorniakov

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Bar Shalem

4Department of Computer Science, Bar-Ilan University, Ramat Gan, Israel.

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Aner Ottolenghi

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Yariv Greenshpan

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Rachel Steinberg

5Soroka University Medical Center, Beer-Sheva, Israel.

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Avishay Edri

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Roni Gillis

6Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Michal Goldhirsh

6Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Khen Moscovici

6Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Sinai Sachren

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Lilach M. Friedman

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Lior Nesher

5Soroka University Medical Center, Beer-Sheva, Israel.

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Yonat Shemer-Avni

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

5Soroka University Medical Center, Beer-Sheva, Israel.

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Angel Porgador

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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For correspondence: angel@bgu.ac.il shental@openu.ac.il thertz@bgu.ac.il

Tomer Hertz

2Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

7Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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