Research ArticleCORONAVIRUS

Molecular characterization of ebselen binding activity to SARS-CoV-2 main protease

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Science Advances  11 Sep 2020:
Vol. 6, no. 37, eabd0345
DOI: 10.1126/sciadv.abd0345

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  • RE: Ebselen May Work by Reducing Testosterone

    I suggest the basis of the findings of Menéndez, et al., is low testosterone. Ebselen is known to lower testosterone. It is my hypothesis that COVID-19 infection and subsequent pathology are caused by low dehydroepiandrosterone (DHEA). It is known that DHEA protects against a number of pathogenic viruses. ("Protection by dehydroepiandrosterone in mice infected with viral encephalitis." Arch Virol. 1991;120(3-4):263-71. doi: 10.1007/BF01310481). While I think DHEA and testosterone work together in human evolution, disruptions of the ratio can reduce the effects of DHEA, such as the anti-viral just described. High testosterone can do this. Furthermore, I think human evolution is ongoing in selection for testosterone. Therefore, periodically, signs of this occur; currently COVID-19 is one of them; the flu epidemic of 1918 is another. By reducing testosterone, Ebselen can ameliorate the virulence of COVID-19. In support of the foregoing, dexamethasone is being used for the same purpose, ameliorate COVID-19. Dexamethasone reduces testosterone.

    Competing Interests: None declared.

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