Research ArticleVIROLOGY

A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite

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Science Advances  16 Sep 2020:
Vol. 6, no. 38, eabb1328
DOI: 10.1126/sciadv.abb1328

Article Information

vol. 6 no. 38

PubMed: 
Online ISSN: 
History: 
  • Received for publication February 1, 2020
  • Accepted for publication July 31, 2020
  • .

Author Information

  1. Sonu Kumar1,2,3,*,
  2. Bin Ju4,5,*,
  3. Benjamin Shapero1,
  4. Xiaohe Lin1,
  5. Li Ren4,
  6. Lei Zhang1,
  7. Dan Li4,
  8. Zehua Zhou5,
  9. Yi Feng4,
  10. Cindy Sou1,
  11. Colin J. Mann1,
  12. Yanling Hao4,
  13. Anita Sarkar1,2,3,
  14. Jiali Hou4,
  15. Christian Nunnally1,
  16. Kunxue Hong4,
  17. Shuo Wang4,
  18. Xiangyang Ge4,
  19. Bin Su6,
  20. Elise Landais2,7,8,
  21. Devin Sok2,3,7,8,
  22. Michael B. Zwick7,
  23. Linling He1,
  24. Jiang Zhu1,,
  25. Ian A. Wilson1,2,3,9, and
  26. Yiming Shao4,5,10,
  1. 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  2. 2IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  3. 3Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.
  4. 4State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Changping District, Beijing 102206, China.
  5. 5School of Medicine, Nankai University, Nankai District, Tianjin 300071, China.
  6. 6Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui Province 230601, China.
  7. 7Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  8. 8International AIDS Vaccine Initiative, New York, NY 10004, USA.
  9. 9Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  10. 10The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, China.
  1. Corresponding author. Email: jiang{at}scripps.edu (J.Z.); wilson{at}scripps.edu (I.A.W.); yshao{at}bjmu.edu.cn (Y.S.)
  • * These authors contributed equally to this work.

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