Research ArticlePHYSIOLOGY

FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity

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Science Advances  16 Sep 2020:
Vol. 6, no. 38, eabc8561
DOI: 10.1126/sciadv.abc8561

Article Information

vol. 6 no. 38

Online ISSN: 
  • Received for publication May 18, 2020
  • Accepted for publication August 3, 2020
  • .

Author Information

  1. Jun Ren1,2,*,
  2. Mingming Sun1,3,*,
  3. Hao Zhou3,4,*,
  4. Amir Ajoolabady3,5,
  5. Yuan Zhou6,
  6. Jun Tao7,
  7. James R. Sowers8 and
  8. Yingmei Zhang1,
  1. 1Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  2. 2Department of Pathology, University of Washington Seattle, Seattle, WA 98195, USA.
  3. 3University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.
  4. 4Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing 100853, China.
  5. 5Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5185715179, Iran.
  6. 6Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
  7. 7Department of Cardiovascular Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510000, China.
  8. 8Diabetes and Cardiovascular Research Center, University of Missouri Columbia, Columbia, MO 65212, USA.
  1. Corresponding author. Email: zhangym197951{at}
  • * These authors contributed equally to this work.


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