Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid

Ritu Raman; Erin B. Rousseau; Michael Wade; Allison Tong; Max J. Cotler; Jenevieve Kuang; Alejandro Aponte Lugo; Elizabeth Zhang; Ann M. Graybiel; Forest M. White; Robert Langer; Michael J. Cima

doi:10.1126/sciadv.abb0657

Research ArticleENGINEERING

Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid

View ORCID ProfileRitu Raman ¹,*,
View ORCID ProfileErin B. Rousseau ¹,²,*,
Michael Wade¹,
View ORCID ProfileAllison Tong¹,
View ORCID ProfileMax J. Cotler ¹,²,
Jenevieve Kuang¹,³,
View ORCID ProfileAlejandro Aponte Lugo¹,
Elizabeth Zhang¹,⁴,
View ORCID ProfileAnn M. Graybiel ⁴,⁵,
View ORCID ProfileForest M. White¹,³,⁶,
View ORCID ProfileRobert Langer ¹,⁷ and
View ORCID ProfileMichael J. Cima ¹,⁸,†

¹Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
²Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
³Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁴McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁵Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁶Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁷Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁸Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

↵†Corresponding author. Email: mjcima{at}mit.edu

↵* These authors contributed equally to this work.

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Science Advances 25 Sep 2020:
Vol. 6, no. 39, eabb0657
DOI: 10.1126/sciadv.abb0657

Ritu Raman

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Erin B. Rousseau

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

2Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Michael Wade

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Allison Tong

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Max J. Cotler

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

2Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Jenevieve Kuang

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

3Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Alejandro Aponte Lugo

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Elizabeth Zhang

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

4McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Ann M. Graybiel

4McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

5Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Forest M. White

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

3Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.

6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Robert Langer

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Michael J. Cima

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

8Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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For correspondence: mjcima@mit.edu

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