Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

Junke Long; Chenxuan Yang; Yawen Zheng; Patricia Loughran; Fu Guang; Yiming Li; Hong Liao; Melanie J. Scott; Daolin Tang; Timothy R. Billiar; Meihong Deng

doi:10.1126/sciadv.abc5447

Research ArticleIMMUNOLOGY

Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

View ORCID ProfileJunke Long¹,²,*,
View ORCID ProfileChenxuan Yang³,⁴,*,
Yawen Zheng²,⁵,
View ORCID ProfilePatricia Loughran⁶,⁷,
View ORCID ProfileFu Guang²,⁸,
View ORCID ProfileYiming Li⁹,¹⁰,
Hong Liao⁶,
View ORCID ProfileMelanie J. Scott⁶,
View ORCID ProfileDaolin Tang¹¹,
View ORCID ProfileTimothy R. Billiar⁶,†,‡ and
View ORCID ProfileMeihong Deng⁶,†,‡

¹Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
²Department of Surgery current visiting research scholar, University of Pittsburgh, Pittsburgh, PA, USA.
³Tsinghua University School of Medicine, Beijing, China.
⁴Department of Surgery former visiting research scholar; 10/24/2016 to 7/27/2018, University of Pittsburgh, Pittsburgh, PA, USA.
⁵Department of Urological Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
⁶Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
⁷Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA, USA.
⁸Department of General Surgery, The Third Xiangya Hospital of Central South University, Changsha 410011, China.
⁹Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China.
¹⁰Department of Surgery former visiting research scholar; 9/1/2018 to 1/31/2020, University of Pittsburgh, Pittsburgh, PA, USA.
¹¹Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

↵‡Corresponding author. Email: billiartr{at}upmc.edu (T.R.B.); dengm{at}upmc.edu (M.D.)

↵* These authors contributed equally to this work.
↵† These authors contributed equally to this work as co-senior authors.

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Science Advances 23 Sep 2020:
Vol. 6, no. 39, eabc5447
DOI: 10.1126/sciadv.abc5447

Junke Long

1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

2Department of Surgery current visiting research scholar, University of Pittsburgh, Pittsburgh, PA, USA.

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Chenxuan Yang

3Tsinghua University School of Medicine, Beijing, China.

4Department of Surgery former visiting research scholar; 10/24/2016 to 7/27/2018, University of Pittsburgh, Pittsburgh, PA, USA.

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Yawen Zheng

2Department of Surgery current visiting research scholar, University of Pittsburgh, Pittsburgh, PA, USA.

5Department of Urological Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China.

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Patricia Loughran

6Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

7Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA, USA.

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Fu Guang

2Department of Surgery current visiting research scholar, University of Pittsburgh, Pittsburgh, PA, USA.

8Department of General Surgery, The Third Xiangya Hospital of Central South University, Changsha 410011, China.

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Yiming Li

9Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China.

10Department of Surgery former visiting research scholar; 9/1/2018 to 1/31/2020, University of Pittsburgh, Pittsburgh, PA, USA.

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Hong Liao

6Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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Melanie J. Scott

6Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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Daolin Tang

11Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

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Timothy R. Billiar

6Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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For correspondence: billiartr@upmc.edu dengm@upmc.edu

Meihong Deng

6Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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For correspondence: billiartr@upmc.edu dengm@upmc.edu

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Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

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