Research ArticleHEALTH AND MEDICINE

Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease

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Science Advances  22 Jan 2020:
Vol. 6, no. 4, eaax6646
DOI: 10.1126/sciadv.aax6646

Article Information

vol. 6 no. 4

Online ISSN: 
History: 
  • Received for publication April 17, 2019
  • Accepted for publication October 18, 2019
  • .

Author Information

  1. K. Xhima1,2,
  2. K. Markham-Coultes1,
  3. H. Nedev3,4,
  4. S. Heinen1,
  5. H. U. Saragovi3,4,
  6. K. Hynynen5,6 and
  7. I. Aubert1,2,*
  1. 1Hurvitz Brain Sciences Research Program, Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
  2. 2Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  3. 3Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
  4. 4Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
  5. 5Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
  6. 6Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  1. *Corresponding author. Email: isabelle.aubert{at}sri.utoronto.ca

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