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Research ArticleCELL BIOLOGY
High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance
- View ORCID ProfileDavid B. Lombard1,2,*,
- View ORCID ProfileWilliam J. Kohler1,
- Angela H. Guo1,
- View ORCID ProfileChristi Gendron3,
- View ORCID ProfileMelissa Han1,
- View ORCID ProfileWeiqiao Ding4,
- View ORCID ProfileYang Lyu3,
- View ORCID ProfileTsui-Ting Ching5,
- Feng-Yung Wang6,
- Tuhin S. Chakraborty3,
- View ORCID ProfileZaneta Nikolovska-Coleska1,
- Yuzhu Duan7,
- View ORCID ProfileThomas Girke7,
- View ORCID ProfileAo-Lin Hsu3,4,8,
- Scott D. Pletcher2,3 and
- View ORCID ProfileRichard A. Miller1,2
- 1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
- 2Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
- 3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
- 4Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.
- 5Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan.
- 6Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 112, Taiwan.
- 7Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA, USA.
- 8Research Center for Healthy Aging, China Medical University, Taichung, Taiwan.
- ↵*Corresponding author. Email: davidlom{at}med.umich.edu
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Science Advances 02 Oct 2020:
Vol. 6, no. 40, eaaz7628
DOI: 10.1126/sciadv.aaz7628
Vol. 6, no. 40, eaaz7628
DOI: 10.1126/sciadv.aaz7628
David B. Lombard
1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
2Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
William J. Kohler
1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Angela H. Guo
1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Christi Gendron
3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Melissa Han
1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Weiqiao Ding
4Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.
Yang Lyu
3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Tsui-Ting Ching
5Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan.
Feng-Yung Wang
6Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 112, Taiwan.
Tuhin S. Chakraborty
3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Zaneta Nikolovska-Coleska
1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Yuzhu Duan
7Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA, USA.
Thomas Girke
7Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA, USA.
Ao-Lin Hsu
3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
4Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.
8Research Center for Healthy Aging, China Medical University, Taichung, Taiwan.
Scott D. Pletcher
2Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Richard A. Miller
1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
2Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
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