High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance

David B. Lombard; William J. Kohler; Angela H. Guo; Christi Gendron; Melissa Han; Weiqiao Ding; Yang Lyu; Tsui-Ting Ching; Feng-Yung Wang; Tuhin S. Chakraborty; Zaneta Nikolovska-Coleska; Yuzhu Duan; Thomas Girke; Ao-Lin Hsu; Scott D. Pletcher; Richard A. Miller

doi:10.1126/sciadv.aaz7628

Research ArticleCELL BIOLOGY

High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance

View ORCID ProfileDavid B. Lombard ¹,²,*,
View ORCID ProfileWilliam J. Kohler¹,
Angela H. Guo¹,
View ORCID ProfileChristi Gendron³,
View ORCID ProfileMelissa Han¹,
View ORCID ProfileWeiqiao Ding⁴,
View ORCID ProfileYang Lyu³,
View ORCID ProfileTsui-Ting Ching⁵,
Feng-Yung Wang⁶,
Tuhin S. Chakraborty³,
View ORCID ProfileZaneta Nikolovska-Coleska¹,
Yuzhu Duan⁷,
View ORCID ProfileThomas Girke ⁷,
View ORCID ProfileAo-Lin Hsu³,⁴,⁸,
Scott D. Pletcher ²,³ and
View ORCID ProfileRichard A. Miller ¹,²

¹Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
²Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
³Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
⁴Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.
⁵Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan.
⁶Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 112, Taiwan.
⁷Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA, USA.
⁸Research Center for Healthy Aging, China Medical University, Taichung, Taiwan.

↵*Corresponding author. Email: davidlom{at}med.umich.edu

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Science Advances 02 Oct 2020:
Vol. 6, no. 40, eaaz7628
DOI: 10.1126/sciadv.aaz7628

David B. Lombard

1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

2Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.

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For correspondence: davidlom@med.umich.edu

William J. Kohler

1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

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Angela H. Guo

1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

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Christi Gendron

3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

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Melissa Han

1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

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Weiqiao Ding

4Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.

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Yang Lyu

3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

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Tsui-Ting Ching

5Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan.

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Feng-Yung Wang

6Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 112, Taiwan.

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Tuhin S. Chakraborty

3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

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Zaneta Nikolovska-Coleska

1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

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Yuzhu Duan

7Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA, USA.

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Thomas Girke

7Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA, USA.

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Ao-Lin Hsu

3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

4Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.

8Research Center for Healthy Aging, China Medical University, Taichung, Taiwan.

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Scott D. Pletcher

2Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.

3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

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Richard A. Miller

1Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

2Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.

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