Inhibition of neutral sphingomyelinase 2 promotes remyelination

Seung-Wan Yoo; Amit Agarwal; Matthew D. Smith; Saja S. Khuder; Emily G. Baxi; Ajit G. Thomas; Camilo Rojas; Mohammed Moniruzzaman; Barbara S. Slusher; Dwight E. Bergles; Peter A. Calabresi; Norman J. Haughey

doi:10.1126/sciadv.aba5210

Research ArticleNEUROSCIENCE

Inhibition of neutral sphingomyelinase 2 promotes remyelination

View ORCID ProfileSeung-Wan Yoo¹,
View ORCID ProfileAmit Agarwal²,*,
View ORCID ProfileMatthew D. Smith¹,
View ORCID ProfileSaja S. Khuder¹,
View ORCID ProfileEmily G. Baxi¹,
View ORCID ProfileAjit G. Thomas²,
Camilo Rojas³,
View ORCID ProfileMohammed Moniruzzaman¹,
View ORCID ProfileBarbara S. Slusher¹,²,³,⁴,
View ORCID ProfileDwight E. Bergles ²,⁵,
View ORCID ProfilePeter A. Calabresi ¹,² and
View ORCID ProfileNorman J. Haughey ¹,⁴,†

¹Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
²The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
³Department of Comparative Medicine and Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
⁴Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
⁵Johns Hopkins University Kavli Neuroscience Discovery Institute, Baltimore, MD 21287, USA.

↵†Corresponding author. Email: nhaughe1{at}jhmi.edu

↵* Present address: Schaller Research Group, Institute for Anatomy and Cell Biology, Heidelberg University, 69120 Heidelberg, Germany.

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Science Advances 02 Oct 2020:
Vol. 6, no. 40, eaba5210
DOI: 10.1126/sciadv.aba5210

Seung-Wan Yoo

1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Amit Agarwal

2The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Matthew D. Smith

1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Saja S. Khuder

1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Emily G. Baxi

1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Ajit G. Thomas

2The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Camilo Rojas

3Department of Comparative Medicine and Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Mohammed Moniruzzaman

1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Barbara S. Slusher

1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

3Department of Comparative Medicine and Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

4Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Dwight E. Bergles

2The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

5Johns Hopkins University Kavli Neuroscience Discovery Institute, Baltimore, MD 21287, USA.

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Peter A. Calabresi

1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Norman J. Haughey

1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

4Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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For correspondence: nhaughe1@jhmi.edu

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