Research ArticleRESEARCH METHODS

Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium

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Science Advances  30 Sep 2020:
Vol. 6, no. 40, eabd0480
DOI: 10.1126/sciadv.abd0480

Article Information

vol. 6 no. 40

PubMed: 
Online ISSN: 
History: 
  • Received for publication May 28, 2020
  • Accepted for publication August 6, 2020
  • .

Author Information

  1. Yumiko Mizukoshi1,*,
  2. Koh Takeuchi2,*,,
  3. Yuji Tokunaga2,
  4. Hitomi Matsuo1,
  5. Misaki Imai1,
  6. Miwa Fujisaki1,
  7. Hajime Kamoshida1,
  8. Takeshi Takizawa3,
  9. Hiroyuki Hanzawa3 and
  10. Ichio Shimada4,5,
  1. 1Japan Biological Informatics Consortium, Tokyo 135-0063, Japan.
  2. 2National Institute of Advanced Industrial Science and Technology (AIST), Molecular Profiling Research Center for Drug Discovery (molprof) and Cellular and Molecular Biotechnology Research Institute, Tokyo 135-0063, Japan.
  3. 3Daiichi Sankyo RD Novare Co. Ltd., Tokyo 134-8630, Japan.
  4. 4Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
  5. 5RIKEN, Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan.
  1. Corresponding author. Email: koh-takeuchi{at}aist.go.jp (K.T.); ichio.shimada{at}riken.jp (I.S.)
  • * These authors contributed equally to this work.

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