Research ArticleSTRUCTURAL BIOLOGY
Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1
- View ORCID ProfileOlivier Soubias1,*,
- Shashank Pant2,*,
- View ORCID ProfileFrank Heinrich3,4,*,
- View ORCID ProfileYue Zhang1,
- Neeladri Sekhar Roy5,
- View ORCID ProfileJess Li1,
- Xiaoying Jian5,
- View ORCID ProfileMarielle E. Yohe6,
- View ORCID ProfilePaul A. Randazzo5,
- View ORCID ProfileMathias Lösche3,4,7,†,
- View ORCID ProfileEmad Tajkhorshid2,† and
- View ORCID ProfileR. Andrew Byrd1,†
- 1Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.
- 2NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
- 3Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
- 4NIST Center for Neutron Research, Gaithersburg, MD 20878, USA.
- 5Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
- 6Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
- 7Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
- ↵†Corresponding author. Email: loesche{at}andrew.cmu.edu (M.L.); emad{at}life.illinois.edu (E.T.); byrdra{at}mail.nih.gov (R.A.B.)
↵* These authors contributed equally to this work.
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Science Advances 30 Sep 2020:
Vol. 6, no. 40, eabd1882
DOI: 10.1126/sciadv.abd1882
Vol. 6, no. 40, eabd1882
DOI: 10.1126/sciadv.abd1882
Olivier Soubias
1Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.
Shashank Pant
2NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Frank Heinrich
3Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
4NIST Center for Neutron Research, Gaithersburg, MD 20878, USA.
Yue Zhang
1Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.
Neeladri Sekhar Roy
5Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jess Li
1Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.
Xiaoying Jian
5Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Marielle E. Yohe
6Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Paul A. Randazzo
5Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mathias Lösche
3Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
4NIST Center for Neutron Research, Gaithersburg, MD 20878, USA.
7Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Emad Tajkhorshid
2NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
R. Andrew Byrd
1Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.
