Research ArticleSTRUCTURAL BIOLOGY
Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of Vo complex
- View ORCID ProfileSoung-Hun Roh1,*,†,
- View ORCID ProfileMrinal Shekhar2,3,*,
- View ORCID ProfileGrigore Pintilie4,
- View ORCID ProfileChristophe Chipot3,5,
- View ORCID ProfileStephan Wilkens6,†,
- View ORCID ProfileAbhishek Singharoy2,† and
- View ORCID ProfileWah Chiu4,7,†
- 1School of Biological Sciences, Seoul National University, Seoul 08826, South Korea.
- 2Biodesign Institute, School of Molecular Sciences, Arizona State University, Tempe, AZ 85801, USA.
- 3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
- 4Department of Bioengineering, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
- 5Laboratoire International Associé CNRS-UIUC, UMR 7019, Université de Lorraine, 54506 Vandœuvre-lès-Nancy, France.
- 6Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
- 7Division of Cryo-EM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA.
- ↵†Corresponding author. Email: wahc{at}stanford.edu (W.C.); shroh{at}snu.ac.kr (S.-H.R.); asinghar{at}asu.edu (A.S.); wilkenss{at}upstate.edu (S.W.)
↵* These authors contributed equally to this work.
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Science Advances 07 Oct 2020:
Vol. 6, no. 41, eabb9605
DOI: 10.1126/sciadv.abb9605
Vol. 6, no. 41, eabb9605
DOI: 10.1126/sciadv.abb9605
Soung-Hun Roh
1School of Biological Sciences, Seoul National University, Seoul 08826, South Korea.
Mrinal Shekhar
2Biodesign Institute, School of Molecular Sciences, Arizona State University, Tempe, AZ 85801, USA.
3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Grigore Pintilie
4Department of Bioengineering, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Christophe Chipot
3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
5Laboratoire International Associé CNRS-UIUC, UMR 7019, Université de Lorraine, 54506 Vandœuvre-lès-Nancy, France.
Stephan Wilkens
6Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Abhishek Singharoy
2Biodesign Institute, School of Molecular Sciences, Arizona State University, Tempe, AZ 85801, USA.
Wah Chiu
4Department of Bioengineering, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
7Division of Cryo-EM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA.
