Research ArticleDEVELOPMENTAL NEUROSCIENCE
NAD+-mediated rescue of prenatal forebrain angiogenesis restores postnatal behavior
- View ORCID ProfileSivan Subburaju1,2,3,
- Sarah Kaye1,3,
- View ORCID ProfileYong Kee Choi1,2,3,
- View ORCID ProfileJugajyoti Baruah1,2,3,
- Debkanya Datta1,2,3,
- View ORCID ProfileJun Ren4,
- View ORCID ProfileAshwin Srinivasan Kumar4,5,
- View ORCID ProfileGabor Szabo6,
- View ORCID ProfileDai Fukumura4,
- View ORCID ProfileRakesh K. Jain4,
- Abdallah Elkhal7,8 and
- View ORCID ProfileAnju Vasudevan1,2,*
- 1Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA 91105, USA.
- 2Department of Psychiatry, Harvard Medical School, Boston, MA, 02215, USA.
- 3Division of Basic Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA.
- 4Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
- 5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 6Institute of Experimental Medicine, Medical Gene Technology Unit, 1083 Budapest, Hungary.
- 7Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
- 8Division of Transplantation, Brigham and Women’s Hospital, 221 Longwood Avenue, EBRC 309, Boston, MA 02115, USA.
- ↵*Corresponding author. Email: anju.vasudevan{at}hmri.org
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Science Advances 09 Oct 2020:
Vol. 6, no. 41, eabb9766
DOI: 10.1126/sciadv.abb9766
Vol. 6, no. 41, eabb9766
DOI: 10.1126/sciadv.abb9766
Sivan Subburaju
1Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA 91105, USA.
2Department of Psychiatry, Harvard Medical School, Boston, MA, 02215, USA.
3Division of Basic Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA.
Sarah Kaye
1Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA 91105, USA.
3Division of Basic Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA.
Yong Kee Choi
1Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA 91105, USA.
2Department of Psychiatry, Harvard Medical School, Boston, MA, 02215, USA.
3Division of Basic Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA.
Jugajyoti Baruah
1Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA 91105, USA.
2Department of Psychiatry, Harvard Medical School, Boston, MA, 02215, USA.
3Division of Basic Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA.
Debkanya Datta
1Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA 91105, USA.
2Department of Psychiatry, Harvard Medical School, Boston, MA, 02215, USA.
3Division of Basic Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA.
Jun Ren
4Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Ashwin Srinivasan Kumar
4Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Gabor Szabo
6Institute of Experimental Medicine, Medical Gene Technology Unit, 083 Budapest, Hungary.
Dai Fukumura
4Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Rakesh K. Jain
4Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Abdallah Elkhal
7Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
8Division of Transplantation, Brigham and Women’s Hospital, 221 Longwood Avenue, EBRC 309, Boston, MA 02115, USA.
Anju Vasudevan
1Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA 91105, USA.
2Department of Psychiatry, Harvard Medical School, Boston, MA, 02215, USA.
