Research ArticleHEALTH AND MEDICINE

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

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Science Advances  09 Oct 2020:
Vol. 6, no. 41, eabc7031
DOI: 10.1126/sciadv.abc7031

Article Information

vol. 6 no. 41

PubMed: 
Online ISSN: 
History: 
  • Received for publication May 13, 2020
  • Accepted for publication August 26, 2020
  • .

Author Information

  1. Yutong Zhou1,*,
  2. Feiyan Zhu2,*,
  3. Yang Liu2,3,*,
  4. Meng Zheng2,,
  5. Yibin Wang2,
  6. Dongya Zhang2,
  7. Yasutaka Anraku4,
  8. Yan Zou2,5,
  9. Jia Li3,
  10. Haigang Wu2,
  11. Xiaobin Pang3,
  12. Wei Tao6,
  13. Olga Shimoni7,
  14. Ashley I. Bush8,
  15. Xue Xue1, and
  16. Bingyang Shi2,5,
  1. 1State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300350, China.
  2. 2Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
  3. 3School of Pharmacy, Henan University, Kaifeng, Henan 475004, China.
  4. 4Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  5. 5Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW 2109, Australia.
  6. 6Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Institute for Biomedical Materials & Devices (IBMD), School of Mathematical and Physical Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
  8. 8Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia.
  1. Corresponding author. Email: bs{at}henu.edu.cn (B.S.); xuexue{at}nankai.edu.cn (X.X.); mzheng{at}henu.edu.cn (M.Z.)
  • * These authors contributed equally to this work.

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