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Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma

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Science Advances  16 Oct 2020:
Vol. 6, no. 42, eabb5427
DOI: 10.1126/sciadv.abb5427

Article Information

vol. 6 no. 42

PubMed: 
Online ISSN: 
History: 
  • Received for publication March 2, 2020
  • Accepted for publication September 1, 2020
  • .

Author Information

  1. Jia Li1,
  2. Sibo Zhao2,3,
  3. Minjung Lee1,
  4. Yue Yin1,
  5. Jin Li1,
  6. Yubin Zhou4,
  7. Leomar Y. Ballester5,6,
  8. Yoshua Esquenazi6,
  9. Roderick H. Dashwood1,
  10. Peter J. A. Davies4,
  11. D. Williams Parsons2,
  12. Xiao-Nan Li2,7,*,
  13. Yun Huang1,* and
  14. Deqiang Sun1,8,9,*
  1. 1Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.
  2. 2Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
  3. 3Department of Hematology and Oncology, Cook Children’s Medical Center, Fort Worth, TX 76104, USA.
  4. 4Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.
  5. 5Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  6. 6Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  7. 7Program of Precision Medicine PDOX Modeling of Pediatric Cancers, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  8. 8Gomics Technology Corporation, 7707 Fannin Street, Suite 200, Houston, TX 77054, USA.
  9. 9Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
  1. *Corresponding author. Email: xli{at}luriechildrens.org (X.-N.L.); yun.huang{at}tamu.edu (Y.H.); dsun{at}gomicstech.com (D.S.)

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