Research ArticleIMMUNOLOGY

The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes

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Science Advances  16 Oct 2020:
Vol. 6, no. 42, eabc5586
DOI: 10.1126/sciadv.abc5586

Article Information

vol. 6 no. 42

Online ISSN: 
  • Received for publication April 30, 2020
  • Accepted for publication September 3, 2020
  • .

Author Information

  1. Christine Bender1,
  2. Teresa Rodriguez-Calvo1,2,
  3. Natalie Amirian1,
  4. Ken T. Coppieters3 and
  5. Matthias G. von Herrath1,4,*
  1. 1Center for Type 1 Diabetes Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
  2. 2The Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Diabetes Research, Munich-Neuherberg, Germany.
  3. 3Global Research Project Management, Novo Nordisk, Måløv, Denmark.
  4. 4The Novo Nordisk Research Center Seattle Inc., Seattle, WA, USA.
  1. *Corresponding author. Email: matthias{at}


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