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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

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Science Advances  16 Oct 2020:
Vol. 6, no. 42, eabd4596
DOI: 10.1126/sciadv.abd4596

Article Information

vol. 6 no. 42

Online ISSN: 
  • Received for publication June 22, 2020
  • Accepted for publication September 1, 2020
  • .

Author Information

  1. Wioletta Rut1,*,,
  2. Zongyang Lv2,3,*,
  3. Mikolaj Zmudzinski1,
  4. Stephanie Patchett4,
  5. Digant Nayak2,3,
  6. Scott J. Snipas5,
  7. Farid El Oualid6,
  8. Tony T. Huang3,,
  9. Miklos Bekes7,,,
  10. Marcin Drag1,5, and
  11. Shaun K. Olsen2,3,
  1. 1Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland.
  2. 2Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  3. 3Department of Biochemistry and Structural Biology University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
  4. 4Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
  5. 5Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
  6. 6UbiQ Bio B.V., 1098 XH, Amsterdam, Netherlands.
  7. 7Independent Consultant.
  1. Corresponding author. Email: wioletta.rut{at} (W.R.); tony.huang{at} (T.T.H.); miklosbekes{at} (M.B.); olsens{at} (S.K.O.); marcin.drag{at} (M.D.)
  • * These authors contributed equally to this work.

  • Present address: Arvinas Inc., 5 Science Park, New Haven, CT 06511, USA.


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