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RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis

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Science Advances  23 Oct 2020:
Vol. 6, no. 43, eaba3058
DOI: 10.1126/sciadv.aba3058

Article Information

vol. 6 no. 43

PubMed: 
Online ISSN: 
History: 
  • Received for publication December 3, 2019
  • Accepted for publication September 9, 2020
  • .

Author Information

  1. Sara Sánchez-Molina1,*,
  2. Elisabet Figuerola-Bou1,
  3. Enrique Blanco2,3,
  4. María Sánchez-Jiménez1,
  5. Pablo Táboas1,
  6. Soledad Gómez1,
  7. Cecilia Ballaré2,3,
  8. Daniel J. García-Domínguez4,
  9. Estela Prada1,
  10. Lourdes Hontecillas-Prieto4,
  11. Ángel M. Carcaboso1,
  12. Óscar M. Tirado5,
  13. Inmaculada Hernández-Muñoz1,6,
  14. Enrique de Álava4,7,
  15. Cinzia Lavarino1,8,
  16. Luciano Di Croce2,3,9,*, and
  17. Jaume Mora1,8,*,
  1. 1Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  2. 2Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
  3. 3Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.
  4. 4Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla-CIBERONC, Department of Pathology, 41013 Seville, Spain.
  5. 5Sarcoma Research Group, Laboratori d’Oncologia Molecular, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL)-CIBERONC, L’Hospitalet de Llobregat, 08908 Barcelona, Spain.
  6. 6Fundació Institut Hospital del Mar d’Investigacions Mèdiques (FIMIM), 08003 Barcelona, Spain.
  7. 7Department of Normal and Pathological Cytology and Histology, School of Medicine, University of Seville, 41009 Seville, Spain.
  8. 8Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  9. 9Institucio Catalana de Recerca i Estudis Avançats (ICREA), Pg Lluis Companys 23, 08010 Barcelona, Spain.
  1. *Corresponding author. Email: ssanchez{at}fsjd.org (S.S.-M.); luciano.dicroce{at}crg.es (L.D.C.); jmora{at}sjdhospitalbarcelona.org (J.M.)
  • These authors contributed equally to this work as co-senior authors.

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