Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis

Andrew L. Wishart; Sydney J. Conner; Justinne R. Guarin; Jackson P. Fatherree; Yifan Peng; Rachel A. McGinn; Rebecca Crews; Stephen P. Naber; Martin Hunter; Andrew S. Greenberg; Madeleine J. Oudin

doi:10.1126/sciadv.abc3175

Research ArticleCANCER

Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis

View ORCID ProfileAndrew L. Wishart¹,
View ORCID ProfileSydney J. Conner¹,
View ORCID ProfileJustinne R. Guarin¹,
View ORCID ProfileJackson P. Fatherree ¹,
Yifan Peng¹,
View ORCID ProfileRachel A. McGinn¹,
View ORCID ProfileRebecca Crews²,
Stephen P. Naber³,
View ORCID ProfileMartin Hunter¹,
View ORCID ProfileAndrew S. Greenberg ²,⁴,⁵ and
View ORCID ProfileMadeleine J. Oudin ¹,*

¹Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
²Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
³Department of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.
⁴Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.
⁵Tufts University School of Medicine, Boston, MA 02111, USA.

↵*Corresponding author. Email: madeleine.oudin{at}tufts.edu

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Science Advances 21 Oct 2020:
Vol. 6, no. 43, eabc3175
DOI: 10.1126/sciadv.abc3175

Andrew L. Wishart

1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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Sydney J. Conner

1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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Justinne R. Guarin

1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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Jackson P. Fatherree

1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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Yifan Peng

1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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Rachel A. McGinn

1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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Rebecca Crews

2Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

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Stephen P. Naber

3Department of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.

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Martin Hunter

1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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Andrew S. Greenberg

2Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

4Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.

5Tufts University School of Medicine, Boston, MA 02111, USA.

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Madeleine J. Oudin

1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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For correspondence: madeleine.oudin@tufts.edu

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Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis

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