Research ArticleSTRUCTURAL BIOLOGY

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions

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Science Advances  30 Oct 2020:
Vol. 6, no. 44, eabc9174
DOI: 10.1126/sciadv.abc9174

Article Information

vol. 6 no. 44

PubMed: 
Online ISSN: 
History: 
  • Received for publication May 20, 2020
  • Accepted for publication September 10, 2020
  • .

Author Information

  1. Marco Lolicato1,*,,
  2. Andrew M. Natale1,*,
  3. Fayal Abderemane-Ali1,
  4. David Crottès2,
  5. Sara Capponi1,,
  6. Ramona Duman3,
  7. Armin Wagner3,
  8. John M. Rosenberg4,
  9. Michael Grabe1,5,§ and
  10. Daniel L. Minor Jr.1,6,7,8,9,§
  1. 1Cardiovascular Research Institute, University of California, San Francisco, CA 93858-2330, USA.
  2. 2Department of Physiology, University of California, San Francisco, CA 93858-2330, USA.
  3. 3Science Division, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.
  4. 4Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
  5. 5Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 93858-2330, USA.
  6. 6Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 93858-2330, USA.
  7. 7California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 93858-2330, USA.
  8. 8Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA, 93858-2330, USA.
  9. 9Molecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720 USA.
  1. §Corresponding author. Email: michael.grabe{at}ucsf.edu (M.G.); daniel.minor{at}ucsf.edu (D.L.M.)
  • * These authors contributed equally to this work.

  • Present address: Department of Molecular Medicine, University of Pavia, Pavia, Italy.

  • Present address: Department of Industrial and Applied Genomics, IBM AI and Cognitive Software Organization, IBM Almaden Research Center, San Jose, CA, USA; NSF Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA.

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