Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection

Lei Tan; Jieni Fu; Fan Feng; Xiangmei Liu; Zhenduo Cui; Bo Li; Yong Han; Yufeng Zheng; Kelvin Wai Kwok Yeung; Zhaoyang Li; Shengli Zhu; Yanqin Liang; Xiaobo Feng; Xianbao Wang; Shuilin Wu

doi:10.1126/sciadv.aba5723

Research ArticleIMMUNOLOGY

Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection

View ORCID ProfileLei Tan¹,*,
View ORCID ProfileJieni Fu²,*,
View ORCID ProfileFan Feng¹,*,
View ORCID ProfileXiangmei Liu¹,†,
View ORCID ProfileZhenduo Cui²,
View ORCID ProfileBo Li³,
View ORCID ProfileYong Han³,
View ORCID ProfileYufeng Zheng⁴,
View ORCID ProfileKelvin Wai Kwok Yeung⁵,
View ORCID ProfileZhaoyang Li²,
View ORCID ProfileShengli Zhu²,
View ORCID ProfileYanqin Liang²,
View ORCID ProfileXiaobo Feng⁶,
View ORCID ProfileXianbao Wang¹ and
View ORCID ProfileShuilin Wu²,†

¹Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.
²School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.
³State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China.
⁴State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
⁵Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
⁶Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

↵†Corresponding author. Email: liuxiangmei1978{at}163.com (X.L.); shuilin.wu{at}gmail.com (S.W.)

↵* These authors contributed equally to this work.

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Science Advances 13 Nov 2020:
Vol. 6, no. 46, eaba5723
DOI: 10.1126/sciadv.aba5723

Lei Tan

1Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.

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Jieni Fu

2School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

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Fan Feng

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Xiangmei Liu

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For correspondence: liuxiangmei1978@163.com shuilin.wu@gmail.com

Zhenduo Cui

2School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

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Bo Li

3State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China.

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Yong Han

3State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China.

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Yufeng Zheng

4State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

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Kelvin Wai Kwok Yeung

5Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.

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Zhaoyang Li

2School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

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Shengli Zhu

2School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

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Yanqin Liang

2School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

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Xiaobo Feng

6Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

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Xianbao Wang

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Shuilin Wu

2School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

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For correspondence: liuxiangmei1978@163.com shuilin.wu@gmail.com

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