LRRK2 mediates tubulation and vesicle sorting from lysosomes

Luis Bonet-Ponce; Alexandra Beilina; Chad D. Williamson; Eric Lindberg; Jillian H. Kluss; Sara Saez-Atienzar; Natalie Landeck; Ravindran Kumaran; Adamantios Mamais; Christopher K. E. Bleck; Yan Li; Mark R. Cookson

doi:10.1126/sciadv.abb2454

Research ArticleCELL BIOLOGY

LRRK2 mediates tubulation and vesicle sorting from lysosomes

View ORCID ProfileLuis Bonet-Ponce¹,
Alexandra Beilina¹,
View ORCID ProfileChad D. Williamson²,
View ORCID ProfileEric Lindberg³,
Jillian H. Kluss¹,
View ORCID ProfileSara Saez-Atienzar⁴,
View ORCID ProfileNatalie Landeck¹,
Ravindran Kumaran¹,
Adamantios Mamais¹,
View ORCID ProfileChristopher K. E. Bleck³,
View ORCID ProfileYan Li⁵ and
View ORCID ProfileMark R. Cookson¹,*

¹Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
²Cell Biology and Neurobiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
³Electron Microscopy Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
⁴Neuromuscular Diseases Research Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
⁵Proteomics Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

↵*Corresponding author: Email: cookson{at}mail.nih.gov

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Science Advances 11 Nov 2020:
Vol. 6, no. 46, eabb2454
DOI: 10.1126/sciadv.abb2454

Luis Bonet-Ponce

1Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Luis Bonet-Ponce

Alexandra Beilina

1Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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Chad D. Williamson

2Cell Biology and Neurobiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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Eric Lindberg

3Electron Microscopy Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Eric Lindberg

Jillian H. Kluss

1Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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Sara Saez-Atienzar

4Neuromuscular Diseases Research Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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Natalie Landeck

1Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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Ravindran Kumaran

1Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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Adamantios Mamais

1Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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Christopher K. E. Bleck

3Electron Microscopy Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Yan Li

5Proteomics Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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Mark R. Cookson

1Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Mark R. Cookson
For correspondence: cookson@mail.nih.gov

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LRRK2 mediates tubulation and vesicle sorting from lysosomes

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