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Research ArticleNEUROSCIENCE
Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation
- View ORCID ProfileA. Nakano-Kobayashi1,*,
- A. Fukumoto2,
- A. Morizane2,
- View ORCID ProfileD. T. Nguyen3,
- T. M. Le3,
- View ORCID ProfileK. Hashida3,
- View ORCID ProfileT. Hosoya4,
- View ORCID ProfileR. Takahashi5,
- View ORCID ProfileJ. Takahashi2,
- View ORCID ProfileO. Hori3 and
- View ORCID ProfileM. Hagiwara1,*
- 1Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
- 2Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
- 3Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
- 4Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
- 5Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
- ↵*Corresponding author. Email: kobayashi.akiko.5e{at}kyoto-u.ac.jp (A.N.-K.); hagiwara.masatoshi.8c{at}kyoto-u.ac.jp (M.H)
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Science Advances 13 Nov 2020:
Vol. 6, no. 46, eabc1428
DOI: 10.1126/sciadv.abc1428
Vol. 6, no. 46, eabc1428
DOI: 10.1126/sciadv.abc1428
A. Nakano-Kobayashi
1Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
A. Fukumoto
2Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
A. Morizane
2Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
D. T. Nguyen
3Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
T. M. Le
3Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
K. Hashida
3Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
T. Hosoya
4Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
R. Takahashi
5Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
J. Takahashi
2Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
O. Hori
3Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
M. Hagiwara
1Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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