Research ArticleNEUROSCIENCE
Determinants of seeding and spreading of α-synuclein pathology in the brain
- View ORCID ProfileMartin T. Henrich1,2,*,
- View ORCID ProfileFanni F. Geibl2,*,
- Harini Lakshminarasimhan1,
- Anna Stegmann2,
- View ORCID ProfileBenoit I. Giasson3,
- View ORCID ProfileXiaobo Mao4,5,
- View ORCID ProfileValina L. Dawson4,5,6,7,
- View ORCID ProfileTed M. Dawson4,5,6,8,
- View ORCID ProfileWolfgang H. Oertel2,† and
- View ORCID ProfileD. James Surmeier1,†,‡
- 1Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
- 2Department of Neurology, Philipps University Marburg, Marburg 35043, Germany.
- 3Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
- 4Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 6Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 7Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 8Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
- ↵‡Corresponding author. Email: j-surmeier{at}northwestern.edu
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Science Advances 11 Nov 2020:
Vol. 6, no. 46, eabc2487
DOI: 10.1126/sciadv.abc2487
Vol. 6, no. 46, eabc2487
DOI: 10.1126/sciadv.abc2487
Martin T. Henrich
1Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
2Department of Neurology, Philipps University Marburg, Marburg 35043, Germany.
Fanni F. Geibl
2Department of Neurology, Philipps University Marburg, Marburg 35043, Germany.
Harini Lakshminarasimhan
1Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Anna Stegmann
2Department of Neurology, Philipps University Marburg, Marburg 35043, Germany.
Benoit I. Giasson
3Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Xiaobo Mao
4Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Valina L. Dawson
4Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
6Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
7Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ted M. Dawson
4Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
6Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
8Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Wolfgang H. Oertel
2Department of Neurology, Philipps University Marburg, Marburg 35043, Germany.
D. James Surmeier
1Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
