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Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

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Science Advances  18 Nov 2020:
Vol. 6, no. 47, eabc3465
DOI: 10.1126/sciadv.abc3465

Article Information

vol. 6 no. 47

Online ISSN: 
  • Received for publication April 20, 2020
  • Accepted for publication September 30, 2020
  • .

Author Information

  1. Benjamin Demarco1,
  2. James P. Grayczyk2,
  3. Elisabet Bjanes2,*,
  4. Didier Le Roy3,
  5. Wulf Tonnus4,
  6. Charles-Antoine Assenmacher2,
  7. Enrico Radaelli2,
  8. Timothée Fettrelet1,
  9. Vanessa Mack1,
  10. Andreas Linkermann4,
  11. Thierry Roger3,
  12. Igor E. Brodsky2,5,
  13. Kaiwen W. Chen1,, and
  14. Petr Broz1,
  1. 1Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.
  2. 2Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.
  3. 3Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Epalinges, Switzerland.
  4. 4Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
  5. 5Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  1. Corresponding author. Email: kaiwen.chen{at} (K.W.C.); petr.broz{at} (P.B.)
  • * Present address: Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.

  • Present address: Immunology Programme, Life Science Institute, and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.


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