Research ArticleCANCER

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

See allHide authors and affiliations

Science Advances  18 Nov 2020:
Vol. 6, no. 47, eabc9450
DOI: 10.1126/sciadv.abc9450

Article Information

vol. 6 no. 47

Online ISSN: 
  • Received for publication May 22, 2020
  • Accepted for publication October 2, 2020
  • .

Author Information

  1. Daniel Rosenblum1,2,3,4,*,
  2. Anna Gutkin1,2,3,4,*,
  3. Ranit Kedmi1,2,3,4,5,
  4. Srinivas Ramishetti1,2,3,4,
  5. Nuphar Veiga1,2,3,4,
  6. Ashley M. Jacobi6,
  7. Mollie S. Schubert6,
  8. Dinorah Friedmann-Morvinski7,
  9. Zvi R. Cohen8,
  10. Mark A. Behlke6,
  11. Judy Lieberman9 and
  12. Dan Peer1,2,3,4,
  1. 1Laboratory of Precision Nanomedicine, The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel-Aviv, Israel.
  2. 2Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
  3. 3Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel.
  4. 4Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel.
  5. 5Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
  6. 6Integrated DNA Technologies Inc., Coralville, IA 52241, USA.
  7. 7Sagol School of Neuroscience, Department of Biochemistry and Molecular Biology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  8. 8Department of Neurosurgery, Sheba Medical Center, Ramat-Gan, and Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  9. 9Program in Cellular and Molecular Medicine, Boston Children’s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: peer{at}
  • * These authors contributed equally to this work.


Article usage

Article usage: to


Stay Connected to Science Advances

Navigate This Article