Research ArticleDISEASES AND DISORDERS
Germline genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes
- View ORCID ProfileXue Xu1,2,3,4,*,
- View ORCID ProfileYuan Zhou5,*,
- View ORCID ProfileXiaowen Feng2,3,4,5,*,
- View ORCID ProfileXiong Li2,3,4,6,*,
- View ORCID ProfileMohammad Asad2,3,4,
- Derek Li2,3,4,
- View ORCID ProfileBo Liao7,†,
- View ORCID ProfileJianqiang Li1,†,
- View ORCID ProfileQinghua Cui5,† and
- View ORCID ProfileEdwin Wang2,3,4,†
- 1College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.
- 2Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
- 3Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
- 4Arnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
- 5Department of Biomedical Informatics, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.
- 6School of Software, East China Jiaotong University, Nanchang, China.
- 7School of Mathematics and Statistics, Hainan Normal University, Haikou, China.
- ↵†Corresponding author. Email: edwin.wang{at}ucalgary.ca (E.W.); cuiqinghua{at}hsc.pku.edu.cn (Q.C.); dragonbw{at}163.com (B.L.); lijq{at}szu.edu.cn (J.L.)
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Advances 27 Nov 2020:
Vol. 6, no. 48, eaba4905
DOI: 10.1126/sciadv.aba4905
Vol. 6, no. 48, eaba4905
DOI: 10.1126/sciadv.aba4905
Xue Xu
1College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.
2Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
3Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
4Arnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Yuan Zhou
5Department of Biomedical Informatics, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.
Xiaowen Feng
2Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
3Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
4Arnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
5Department of Biomedical Informatics, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.
Xiong Li
2Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
3Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
4Arnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
6School of Software, East China Jiaotong University, Nanchang, China.
Mohammad Asad
2Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
3Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
4Arnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Derek Li
2Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
3Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
4Arnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Bo Liao
7School of Mathematics and Statistics, Hainan Normal University, Haikou, China.
Jianqiang Li
1College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.
Qinghua Cui
5Department of Biomedical Informatics, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.
Edwin Wang
2Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
3Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
4Arnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
