Research ArticleCELL BIOLOGY

On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias

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Science Advances  27 Nov 2020:
Vol. 6, no. 48, eabc4397
DOI: 10.1126/sciadv.abc4397

Article Information

vol. 6 no. 48

Online ISSN: 
  • Received for publication April 24, 2020
  • Accepted for publication October 2, 2020
  • .

Author Information

  1. Xiaohe Tian1,2,3,*,
  2. Diana M. Leite4,5,*,
  3. Edoardo Scarpa4,5,6,*,
  4. Sophie Nyberg4,5,7,,
  5. Gavin Fullstone4,5,8,
  6. Joe Forth4,5,
  7. Diana Matias4,5,
  8. Azzurra Apriceno4,5,
  9. Alessandro Poma4,5,
  10. Aroa Duro-Castano4,5,
  11. Manish Vuyyuru5,9,,
  12. Lena Harker-Kirschneck5,9,
  13. Anđela Šarić5,9,
  14. Zhongping Zhang3,10,
  15. Pan Xiang1,
  16. Bin Fang2,
  17. Yupeng Tian2,
  18. Lei Luo11,
  19. Loris Rizzello4,5,12 and
  20. Giuseppe Battaglia2,4,5,12,13,§
  1. 1School of Life Science, Anhui University, Hefei, P. R. China.
  2. 2Department of Chemistry, Anhui University, Hefei, P. R. China.
  3. 3Institute of Physical Science and Information Technology, Anhui University, Hefei, P. R. China.
  4. 4Department of Chemistry, University College London, London, UK.
  5. 5Institute for the Physics of Living Systems, University College London, London, UK.
  6. 6SomaNautix Ltd., London, UK.
  7. 7Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
  8. 8Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
  9. 9Department of Physics and Astronomy, University College London, London, UK.
  10. 10CAS Center for Excellence in Nanoscience, Institute of Intelligent Machines, Chinese Academy of Science, Hefei, China.
  11. 11College of Pharmaceutical Sciences, Southwest University, Chongqing, P. R. China.
  12. 12Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.
  13. 13Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
  1. §Corresponding author. Email: g.battaglia{at}
  • * These authors contributed equally to this work.

  • Present address: Medicines Discovery Catapult, Alderley Park, Alderley Edge, Cheshire SK10 4TG, UK.

  • Present address: John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.


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