Research ArticleSTRUCTURAL BIOLOGY
Inactivation-mimicking block of the epithelial calcium channel TRPV6
- View ORCID ProfileRajesh Bhardwaj1,*,
- View ORCID ProfileSonja Lindinger2,*,
- View ORCID ProfileArthur Neuberger3,*,
- Kirill D. Nadezhdin3,*,
- Appu K. Singh3,4,
- View ORCID ProfileMicael R. Cunha5,
- View ORCID ProfileIsabella Derler2,
- View ORCID ProfileGergely Gyimesi1,
- View ORCID ProfileJean-Louis Reymond5,
- View ORCID ProfileMatthias A. Hediger1,†,
- View ORCID ProfileChristoph Romanin2,† and
- View ORCID ProfileAlexander I. Sobolevsky3,†
- 1Department of Nephrology and Hypertension and Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland.
- 2Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
- 3Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.
- 4Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
- 5Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
- ↵†Corresponding author. Email: matthias.hediger{at}ibmm.unibe.ch (M.A.H.); christoph.romanin{at}jku.at (C.R.); as4005{at}cumc.columbia.edu (A.I.S.)
↵* These authors contributed equally to this work.
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Science Advances 27 Nov 2020:
Vol. 6, no. 48, eabe1508
DOI: 10.1126/sciadv.abe1508
Vol. 6, no. 48, eabe1508
DOI: 10.1126/sciadv.abe1508
Rajesh Bhardwaj
1Department of Nephrology and Hypertension and Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland.
Sonja Lindinger
2Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Arthur Neuberger
3Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.
Kirill D. Nadezhdin
3Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.
Appu K. Singh
3Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.
4Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Micael R. Cunha
5Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Isabella Derler
2Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Gergely Gyimesi
1Department of Nephrology and Hypertension and Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland.
Jean-Louis Reymond
5Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Matthias A. Hediger
1Department of Nephrology and Hypertension and Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland.
Christoph Romanin
2Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Alexander I. Sobolevsky
3Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.
