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The chaperonin CCT controls T cell receptor–driven 3D configuration of centrioles

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Science Advances  02 Dec 2020:
Vol. 6, no. 49, eabb7242
DOI: 10.1126/sciadv.abb7242

Article Information

vol. 6 no. 49

Online ISSN: 
  • Received for publication March 13, 2020
  • Accepted for publication October 19, 2020
  • .

Author Information

  1. N. B. Martin-Cofreces1,2,3,*,,
  2. F. J. Chichon4,,
  3. E. Calvo3,5,
  4. D. Torralba1,2,
  5. E. Bustos-Moran1,2,
  6. S. G. Dosil1,2,
  7. A. Rojas-Gomez1,2,
  8. E. Bonzon-Kulichenko3,5,
  9. J. A. Lopez5,
  10. J. Otón6,
  11. A. Sorrentino7,
  12. J. C. Zabala8,
  13. I. Vernos9,10,11,
  14. J. Vazquez3,5,
  15. J. M. Valpuesta4,*, and
  16. F. Sanchez-Madrid1,2,3,*,
  1. 1Immunology Service, Hospital Universitario de la Princesa, UAM, IIS-IP. Madrid, 28006 Spain.
  2. 2Area of Vascular Pathophysiology, Laboratory of Intercellular Communication, Fundación Centro Nacional de Investigaciones Cardiovasculares-Carlos III, Madrid, 28029 Spain.
  3. 3Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Spain.
  4. 4Department of Macromolecular Structure, Computational Systems Biology Group, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, 28049, Spain.
  5. 5Laboratory of Cardiovascular Proteomics. Fundación Centro Nacional de Investigaciones Cardiovasculares-Carlos III, Madrid, 28029 Spain.
  6. 6Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  7. 7ALBA Synchrotron Light Source, Cerdanyola del Vallès, Barcelona 08290, Spain.
  8. 8Departament of Molecular Biology, Facultad de Medicina, Universidad de Cantabria, Santander, 39005 Spain.
  9. 9Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, Barcelona, 08003, Spain.
  10. 10Universitat Pompeu Fabra (UPF), Dr Aiguader 88, Barcelona 08003, Spain.
  11. 11ICREA, Pg. Lluis Companys 23, Barcelona 08010, Spain.
  1. *Corresponding author. Email: fsmadrid{at} (F.S.-M.); jmv{at} (J.M.V.); noa.martin{at} (N.B.M.-C.)
  • These authors contributed equally to this work.

  • These authors contributed equally to this work.


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