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Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo

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Science Advances  04 Dec 2020:
Vol. 6, no. 49, eabc6983
DOI: 10.1126/sciadv.abc6983

Article Information

vol. 6 no. 49

Online ISSN: 
  • Received for publication May 8, 2020
  • Accepted for publication October 22, 2020
  • .

Author Information

  1. Sabah Mozafari1,2,3,4,
  2. Laura Starost5,6,
  3. Blandine Manot-Saillet7,8,
  4. Beatriz Garcia-Diaz1,2,3,4,
  5. Yu Kang T. Xu9,*,
  6. Delphine Roussel1,2,3,4,
  7. Marion J. F. Levy1,2,3,4,
  8. Linda Ottoboni10,
  9. Kee-Pyo Kim6,
  10. Hans R. Schöler6,
  11. Timothy E. Kennedy9,
  12. Jack P. Antel11,
  13. Gianvito Martino10,
  14. Maria Cecilia Angulo7,8,
  15. Tanja Kuhlmann5,6 and
  16. Anne Baron-Van Evercooren1,2,3,4,
  1. 1INSERM, U1127, F-75013 Paris, France.
  2. 2CNRS, UMR 7225, F-75013 Paris, France.
  3. 3Sorbonne Université UPMC Paris 06, UM-75, F-75005, Paris, France.
  4. 4ICM-GH Pitié-Salpêtrière, F-75013, Paris, France.
  5. 5Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.
  6. 6Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.
  7. 7Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM, Université de Paris, U1266, F-75014 Paris, France.
  8. 8GHU PARIS Psychiatrie & Neurosciences, Paris, France.
  9. 9McGill Program in Neuroengineering, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
  10. 10Institute of Experimental Neurology-DIBIT 2, Division of Neuroscience, IRCCS San Raffaele Hospital and Vita San Raffaele University, Milan, Italy.
  11. 11Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
  1. Corresponding author. Email: anne.baron{at}
  • * Present address: Department of Neuroscience, Johns Hopkins University School of Medicine, MD, USA.


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