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Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers

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Science Advances  29 Jan 2020:
Vol. 6, no. 5, eaay2611
DOI: 10.1126/sciadv.aay2611

Article Information

vol. 6 no. 5

Online ISSN: 
History: 
  • Received for publication June 5, 2019
  • Accepted for publication November 20, 2019
  • .

Author Information

  1. Mihriban Karaayvaz-Yildirim1,
  2. Rebecca E. Silberman2,*,
  3. Adam Langenbucher1,*,
  4. Srinivas Vinod Saladi1,3,4,*,
  5. Kenneth N. Ross1,4,
  6. Elena Zarcaro1,
  7. Andrea Desmond1,
  8. Murat Yildirim5,
  9. Varunika Vivekanandan1,
  10. Hiranmayi Ravichandran6,
  11. Ravindra Mylavagnanam6,
  12. Michelle C. Specht7,
  13. Sridhar Ramaswamy1,4,
  14. Michael Lawrence1,4,6,
  15. Angelika Amon2 and
  16. Leif W. Ellisen1,
  1. 1Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  2. 2Koch Institute for Integrative Cancer Research, Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  3. 3Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.
  4. 4Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  5. 5Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  6. 6Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  7. 7Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
  1. Corresponding author. Email: lellisen{at}mgh.harvard.edu
  • * These authors contributed equally to this work.

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