Research ArticleSTRUCTURAL BIOLOGY
Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography
- View ORCID ProfileKate L. White1,2,*,
- View ORCID ProfileJitin Singla1,3,
- View ORCID ProfileValentina Loconte4,
- View ORCID ProfileJian-Hua Chen2,5,
- Axel Ekman5,
- Liping Sun4,
- View ORCID ProfileXianjun Zhang1,
- John Paul Francis6,
- View ORCID ProfileAngdi Li4,
- Wen Lin7,
- View ORCID ProfileKaylee Tseng1,
- Gerry McDermott2,5,
- View ORCID ProfileFrank Alber1,3,
- View ORCID ProfileAndrej Sali8,*,
- View ORCID ProfileCarolyn Larabell2,5,* and
- View ORCID ProfileRaymond C. Stevens1,4,7,*
- 1Department of Biological Sciences, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
- 2Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
- 3Institute for Quantitative and Computational Biosciences, Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- 4iHuman Institute, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
- 5Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
- 6Department of Computer Science, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
- 7Department of Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
- 8California Institute for Quantitative Biosciences, Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
- ↵*Corresponding author. Email: stevens{at}usc.edu (R.C.S.); calarabell{at}lbl.gov (C.L.); sali{at}salilab.org (A.S.); katewhit{at}usc.edu (K.L.W.)
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Science Advances 09 Dec 2020:
Vol. 6, no. 50, eabc8262
DOI: 10.1126/sciadv.abc8262
Vol. 6, no. 50, eabc8262
DOI: 10.1126/sciadv.abc8262
Kate L. White
1Department of Biological Sciences, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
2Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Jitin Singla
1Department of Biological Sciences, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
3Institute for Quantitative and Computational Biosciences, Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Valentina Loconte
4iHuman Institute, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Jian-Hua Chen
2Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
5Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Axel Ekman
5Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Liping Sun
4iHuman Institute, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Xianjun Zhang
1Department of Biological Sciences, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
John Paul Francis
6Department of Computer Science, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Angdi Li
4iHuman Institute, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Wen Lin
7Department of Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Kaylee Tseng
1Department of Biological Sciences, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Gerry McDermott
2Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
5Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Frank Alber
1Department of Biological Sciences, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
3Institute for Quantitative and Computational Biosciences, Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Andrej Sali
8California Institute for Quantitative Biosciences, Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Carolyn Larabell
2Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
5Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Raymond C. Stevens
1Department of Biological Sciences, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
4iHuman Institute, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
7Department of Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
