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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L

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Science Advances  09 Dec 2020:
Vol. 6, no. 50, eabe0751
DOI: 10.1126/sciadv.abe0751

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vol. 6 no. 50

PubMed: 
Online ISSN: 
History: 
  • Received for publication July 29, 2020
  • Accepted for publication October 21, 2020
  • .

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Author Information

  1. Michael Dominic Sacco1,
  2. Chunlong Ma2,
  3. Panagiotis Lagarias3,
  4. Ang Gao2,
  5. Julia Alma Townsend4,
  6. Xiangzhi Meng5,
  7. Peter Dube5,
  8. Xiujun Zhang1,
  9. Yanmei Hu2,
  10. Naoya Kitamura2,
  11. Brett Hurst6,7,
  12. Bart Tarbet6,7,
  13. Michael Thomas Marty4,
  14. Antonios Kolocouris3,
  15. Yan Xiang5,
  16. Yu Chen1,* and
  17. Jun Wang2,*
  1. 1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
  2. 2Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.
  3. 3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens 15771, Greece.
  4. 4Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
  5. 5Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
  6. 6Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA.
  7. 7Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA.
  1. *Corresponding author: Email: junwang{at}pharmacy.arizona.edu (J.W.); ychen1{at}usf.edu (Y.C.)

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Nov 202010956531199
Dec 202044349241355
Jan 20211582662759
Feb 2021982644589
Mar 20211083617786
Apr 20211153482688
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