Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

Tomokazu Tsurugizawa; Kota Tamada; Nobukazu Ono; Sachise Karakawa; Yuko Kodama; Clement Debacker; Junichi Hata; Hideyuki Okano; Akihiko Kitamura; Andrew Zalesky; Toru Takumi

doi:10.1126/sciadv.aav4520

Research ArticleNEUROSCIENCE

Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

View ORCID ProfileTomokazu Tsurugizawa ¹,*,
Kota Tamada²,
View ORCID ProfileNobukazu Ono³,
Sachise Karakawa³,
Yuko Kodama³,
View ORCID ProfileClement Debacker¹,
Junichi Hata²,⁴,
View ORCID ProfileHideyuki Okano²,⁴,
Akihiko Kitamura³,
Andrew Zalesky⁵ and
View ORCID ProfileToru Takumi ²,⁶,*

¹NeuroSpin, Commissariat à l’Energie Atomique et aux Energies Alternatives, CEA Saclay, Gif-sur-Yvette 91191, France.
²RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
³Institute for Innovation, Ajinomoto Co. Inc., Kawasaki 210-8681, Japan.
⁴Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 160-8585, Japan.
⁵Melbourne Neuropsychiatry Centre and Department of Biomedical Engineering, University of Melbourne, Victoria 3010, Australia.
⁶Department of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, Japan.

↵*Corresponding author. Email: tsurugizawa{at}gmail.com (T.Ts.); takumit{at}med.kobe-u.ac.jp (T.Ta.)

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Science Advances 05 Feb 2020:
Vol. 6, no. 6, eaav4520
DOI: 10.1126/sciadv.aav4520

Tomokazu Tsurugizawa

1NeuroSpin, Commissariat à l’Energie Atomique et aux Energies Alternatives, CEA Saclay, Gif-sur-Yvette 91191, France.

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ORCID record for Tomokazu Tsurugizawa
For correspondence: tsurugizawa@gmail.com takumit@med.kobe-u.ac.jp

Kota Tamada

2RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

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Nobukazu Ono

3Institute for Innovation, Ajinomoto Co. Inc., Kawasaki 210-8681, Japan.

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Sachise Karakawa

3Institute for Innovation, Ajinomoto Co. Inc., Kawasaki 210-8681, Japan.

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Yuko Kodama

3Institute for Innovation, Ajinomoto Co. Inc., Kawasaki 210-8681, Japan.

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Clement Debacker

1NeuroSpin, Commissariat à l’Energie Atomique et aux Energies Alternatives, CEA Saclay, Gif-sur-Yvette 91191, France.

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ORCID record for Clement Debacker

Junichi Hata

2RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

4Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 160-8585, Japan.

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Hideyuki Okano

2RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

4Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 160-8585, Japan.

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Akihiko Kitamura

3Institute for Innovation, Ajinomoto Co. Inc., Kawasaki 210-8681, Japan.

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Andrew Zalesky

5Melbourne Neuropsychiatry Centre and Department of Biomedical Engineering, University of Melbourne, Victoria 3010, Australia.

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Toru Takumi

2RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

6Department of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, Japan.

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ORCID record for Toru Takumi
For correspondence: tsurugizawa@gmail.com takumit@med.kobe-u.ac.jp

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Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

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